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[Ecology]-How ribosomes shape the proteome

How ribosomes shape the proteome

Cells are crowded with macromolecules, which limits the diffusion of proteins, especially in prokaryotic cells without active transport in the cytoplasm. While investigating the relationship between crowding, ionic strength and protein diffusion, biochemists made a fascinating discovery: positively charged proteins stick to the surface of ribosome complexes. This explains why most water-soluble proteins carry an overall negative charge.
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