Transgenic non-human mammals US 4736866
The first genetically modified animal, a mouse, was created in 1974
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Genetically modified mammals are an important category of genetically modified organisms. Ralph L. Brinster and Richard Palmiter developed the techniques responsible for transgenic mice, rats, rabbits, sheep, and pigs in the early 1980s, and established many of the first transgenic models of human disease, including the first carcinoma caused by a transgene. The process of genetically engineering animals is a slow, tedious, and expensive process. However, new technologies are making genetic modifications easier and more precise.

The first transgenic (genetically modified) animal was produced by injecting DNA into mouse embryos then implanting the embryos in female mice.

Abstract

A transgenic non-human eukaryotic animal whose germ cells and somatic cells contain an activated oncogene sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage.

https://patents.google.com/patent/US4736866
https://en.wikipedia.org/wiki/Genetically_modified_organism#Transgenic_animals
  

  The advance of genetic engineering makes it quite conceivable that we will begin to design our own evolutionary progress.
                                                                                                                                                              Isaac Asimov
                                                                                                                                          

What is TRANSGENE? What does TRANSGENE mean? TRANSGENE meaning, definition & explanation

https://www.youtube.com/watch?v=l_QxPghUtaE
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